HMG

HMG (menotropin) is a gonadotropin preparation containing FSH and LH activity, studied and clinically used for fertility support and spermatogenesis-focused protocols.

Profile · 01

Overview

HMG, also called menotropin, is a purified gonadotropin preparation containing both FSH and LH activity. It has FDA-approved reproductive uses and a legitimate clinical role in fertility treatment, including off-label male infertility protocols.

The source page focuses on the male-fertility use case, especially when HMG is paired with HCG to support spermatogenesis after hCG alone proves insufficient.

At a Glance

Goal
Support spermatogenesis and fertility through combined FSH and LH activity
Categories
FertilityHormonal SupportSpermatogenesisReproductive Health
Synergistic
HCG · Semen-analysis monitoring · Zinc · CoQ10
Profile · 02

Protocol

Standard male-fertility protocol using a fixed dose three times weekly, typically alongside HCG.

Reconstitute
Add 3.0 mL bacteriostatic water to a 75 IU vial for 25 IU/mL concentration
Typical dose
75 IU per injection, 3 times weekly
Start
75 IU per injection, 3 times weekly
Target
75 IU per injection, 3 times weekly for at least 12 weeks
Frequency
3 times weekly on non-consecutive days (subcutaneous)
Cycle Length
Minimum 12 weeks; optional extension to 16 weeks or longer based on semen response
Timing
Maintain consistent injection days and rotate sites
Route
Subcutaneous
Cycle
12-16 weeks minimum

Inject three times weekly on non-consecutive days. Because the source reconstitution yields a full 3.0 mL injection for 75 IU, this is one of the least convenient protocols in the batch and may require a larger syringe or split dosing at separate sites. Male-fertility use typically also assumes concurrent HCG.

Dose progression

Weeks 1-12
75 IU · 3.0 mL
Weeks 13-16
75 IU · 3.0 mL (optional extension)

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Science · 01

How HMG works.

HMG supplies both FSH and LH activity, which is why it becomes valuable in male fertility settings where hCG alone is not enough to restore meaningful spermatogenesis. The FSH component supports Sertoli-cell function, while LH activity complements testicular steroidogenesis.

Clinical fertility literature supports improved sperm parameters and pregnancy rates when HMG is combined with HCG in appropriately selected patients. The timeline is long because spermatogenesis itself takes months, not weeks.

Science · 02

Effects

Observations from clinical or preclinical literature.

Supports spermatogenesis in hypogonadotropic hypogonadism and selected infertility contexts
Improves sperm count, motility, and morphology when combined with HCG in the right setting
Has a real clinical fertility literature base rather than only speculative peptide folklore
Injection-site pain or irritation is relatively common because volume can be large
Hormonal stimulation can raise estradiol or contribute to gynecomastia risk
Meaningful results often require patience because response may take 3-6 months
Science · 03

Caution

Use caution in hormone-sensitive cancers or complex reproductive endocrine disease
Not useful in primary testicular failure where the gonads are not meaningfully responsive
Use caution in people with thromboembolic risk history or significant hormonal instability
Fertility protocols should involve direct medical supervision and lab follow-up

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Lifestyle · 01

CoFactors

Zinc
Supports spermatogenesis and testosterone production.
Selenium
Supports sperm motility and antioxidant protection.
Vitamin C and Vitamin E
Support oxidative-stress control in sperm biology.
CoQ10
Evidence-based support for sperm motility and mitochondrial function.
L-Carnitine
Relevant to sperm maturation and energy metabolism.
Lifestyle · 02

Life Factors

Complementary strategies for best outcomes.

Maintain healthy body weight and antioxidant-rich nutrition to support fertility
Avoid excessive heat exposure to the testes, including frequent sauna or hot-tub use
Limit alcohol, avoid tobacco, and reduce recreational-drug exposure
Allow enough time for response because spermatogenesis is measured in months, not days
Lifestyle · 03

Metrics

Day-to-day metrics worth tracking through the protocol.

  1. Semen-analysis parameters - primary outcome markers for this protocol
  2. Testosterone and estradiol response - useful where HCG is being run concurrently
  3. Testicular volume and fertility-related symptoms - monitor for trend changes
  4. Injection-site tolerance - especially important because volume is large
Lifestyle · 04

Labs

Baseline and periodic bloodwork to monitor systemic health during the protocol.

Semen analysis
Primary outcome marker and usually the most important follow-up test.
Total and free testosterone
Useful alongside concurrent HCG-based support.
FSH and LH
Helpful for baseline diagnosis and treatment-context interpretation.
Estradiol (E2)
Monitor hormonal spillover during gonadotropin stimulation.
CBC (Complete Blood Count)
General monitoring and baseline screening.
CMP (Comprehensive Metabolic Panel)
Assess broader systemic function during the protocol.
Calculators · 01

Supplies Calculator

Estimates assume the schedule defined for this peptide.

Length
Vial size
Bac. water
Syringe
Vials
0 × 75 IU each…
Syringes
0
Bac. water
0 mL
Swabs
02 per syringe
Calculators · 02

Dose Calculator

Dose Calculator

Vial
Bac. water
Syringe
Dose
Concentration
0IU/mL
Volume per dose
0mL
…
Practice · 01

Preparation

Careful technique preserves potency. Solution should be clear — do not shake.

  1. Allow vial to reach room temperature for 15–20 minutes before reconstitution.
  2. Draw the chosen bacteriostatic water volume with a sterile syringe.
  3. Inject slowly down vial wall; avoid foaming.
  4. Gently swirl/roll until dissolved (do not shake).
  5. Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
  6. Use within 30 days; discard any unused solution after 30 days.
Practice · 02

Technique

General subcutaneous guidance from clinical best-practice resources.

Clean the vial stopper and injection site with alcohol and allow them to dry fully
Use an appropriately sized syringe because a full 75 IU dose in this protocol is 3.0 mL
If splitting the dose, use separate injection sites rather than overfilling one site
Inject slowly and steadily into subcutaneous tissue with proper site rotation
Discard used syringes immediately in a sharps container

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Practice · 03

Storage

Lyophilized
Store at room temp in dry, dark conditions; minimize moisture exposure.
Reconstituted
Refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles. Discard reconstituted vials after 30 days.

Notes

Allow vials to reach room temperature before opening to reduce condensation uptake.
Reference · 01

Notes

HMG is usually not a stand-alone male-fertility peptide; the source assumes concurrent HCG context
The 3.0 mL injection volume is large enough to deserve extra planning and may require split administration
This is a slow protocol where response often takes months rather than weeks
Medical supervision is especially important because the success metrics are hormonal and fertility-specific
PepTribe is an educational platform. This information is for research and learning purposes only and is not medical advice.
Reference · 02

References

  1. International Journal of Reproductive BioMedicine
    Randomized trial of HMG plus HCG versus HCG alone in male infertility.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009564/
  2. Reproductive Medicine and Biology
    Review of gonadotropin therapy for male infertility.
    https://pubmed.ncbi.nlm.nih.gov/30655575/
  3. Menopur product information
    Reconstitution, storage, and menotropin prescribing guidance.
    https://www.ferringfertility.com/menopur/
  4. ASRM
    Gonadotropin use and fertility-treatment practice guidance.
    https://www.asrm.org/practice-guidance/practice-committee-documents/
  5. MedlinePlus
    General subcutaneous injection instructions.
    https://medlineplus.gov/ency/patientinstructions/000430.htm
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